Mäntylä Elina, Niskanen Einari A, Ihalainen Teemu O, Vihinen-Ranta Maija
Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
J Virol. 2015 Nov;89(22):11706-10. doi: 10.1128/JVI.01608-15. Epub 2015 Aug 26.
Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection.
犬细小病毒(CPV)感染会诱导核结构的重组。我们的研究表明,晚期感染会诱导核孔复合体(NPCs)和核纤层蛋白B1的积累,同时细胞核顶端的核纤层蛋白A/C水平会降低。新形成的CPV衣壳位于细胞核顶端靠近NPCs的位置。这些结果表明,细小病毒会导致NPCs在顶端富集以及核纤层的重组,推测这是为了促进晚期感染。