Veterinary Diagnostic Laboratory, Marupi Lifetech Co. Ltd, 103 Fushiocho, Ikeda, Osaka 563-0011, Japan.
Res Vet Sci. 2013 Apr;94(2):368-71. doi: 10.1016/j.rvsc.2012.09.013. Epub 2012 Oct 12.
To clarify the evolution of canine parvovirus 2 (CPV-2) that has recently been epidemic in Japan, VP2 gene sequences at positions 3556-4166 were analyzed in 107 CPV-2 strains obtained from rectal swabs of diarrheic dogs from 2009 to 2011. CPV-2b (95 strains) was more frequently detected than CPV-2a (nine strains), while CPV-2c was not detected. Remaining three strains were identified as the original type CPV-2, which should be derived from vaccines. These findings are similar to the previous results involving Japanese strains, suggesting there has been no great change in the recent CPV-2 epidemic in Japan. This epidemic is the same as that in Taiwan. Furthermore, a 324-lle mutant, which has been reported in Korean and Chinese strains, was detected in 66.7% of CPV-2a strains.
为了阐明在日本近期流行的犬细小病毒 2 型（CPV-2）的进化情况，对 2009 年至 2011 年间从腹泻犬直肠拭子中获得的 107 株 CPV-2 分离株的 VP2 基因序列 3556-4166 位进行了分析。检测到的 CPV-2b（95 株）比 CPV-2a（9 株）更为常见，而未检测到 CPV-2c。其余 3 株被鉴定为原始 CPV-2 型，这应该是来源于疫苗。这些发现与涉及日本分离株的先前结果相似，表明日本近期 CPV-2 流行情况没有重大变化。该流行情况与台湾的相同。此外，在韩国和中国的分离株中报道的 324-ile 突变，在 66.7%的 CPV-2a 株中被检测到。
