有症状的膝关节或手部骨关节炎患者中心血管合并症的高患病率。
High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis.
作者信息
Calvet J, Orellana C, Larrosa M, Navarro N, Chillarón J J, Pedro-Botet J, Galisteo C, García-Manrique M, Gratacós J
机构信息
a Department of Rheumatology , Parc Taulí University Hospital , Sabadell , Spain.
c Department of Medicine , The Autonomous University of Barcelona, UAB , Barcelona , Spain.
出版信息
Scand J Rheumatol. 2016 Jan;45(1):41-44. doi: 10.3109/03009742.2015.1054875. Epub 2015 Aug 31.
OBJECTIVES
To evaluate the frequency of cardiovascular events (CVEs) and metabolic syndrome (MetS) in patients with symptomatic knee or hand osteoarthritis (OA).
METHOD
A cross-sectional study conducted by rheumatologists in a primary care setting. Consecutive symptomatic patients with primary knee or hand OA were included and patients with soft tissue conditions served as the control group. Hypertension, diabetes mellitus, obesity, dyslipidaemia, and CVEs consisting of myocardial infarction, angina, or cerebrovascular disease were recorded.
RESULTS
A total of 254 OA patients (184 with knee OA and 70 with hand OA) and 254 control patients were included. The frequency of obesity was higher in all OA groups and hypertension was more frequent in knee OA. MetS was significantly more frequent in patients with OA as a whole group and in knee or hand OA groups separately (p < 0.001, p = 0.002, and p = 0.007, respectively, vs. control group), with odds ratio (OR) 2.4, 95% confidence interval (CI) 1.26-4.55 in the OA group, OR 2.29, 95% CI 1.15-4.54 in the knee OA group, and OR 2.67, 95% CI 1.15-6.19 in the hand OA group. A higher prevalence of CVEs in the three OA groups was observed compared with the control group.
CONCLUSIONS
A high frequency of MetS and CVEs was observed in OA patients in a primary care setting.
目的
评估有症状的膝关节或手部骨关节炎（OA）患者心血管事件（CVE）和代谢综合征（MetS）的发生频率。
方法
由风湿病学家在初级保健机构进行的一项横断面研究。纳入连续性的原发性膝关节或手部OA有症状患者，软组织疾病患者作为对照组。记录高血压、糖尿病、肥胖症、血脂异常以及包括心肌梗死、心绞痛或脑血管疾病在内的CVE。
结果
共纳入254例OA患者（184例膝关节OA患者和70例手部OA患者）和254例对照患者。所有OA组的肥胖发生率更高，膝关节OA患者的高血压更为常见。MetS在整个OA患者组以及分别在膝关节或手部OA组中显著更常见（与对照组相比，p<0.001、p = 0.002和p = 0.007），OA组的比值比（OR）为2.4，95%置信区间（CI）为1.26 - 4.55，膝关节OA组的OR为2.29，95%CI为1.15 - 4.54，手部OA组的OR为2.67，95%CI为1.15 - 6.19。与对照组相比，在三个OA组中观察到CVE的患病率更高。
结论
在初级保健机构的OA患者中观察到MetS和CVE的高发生率。
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