Nocturne Gaetane, Pavy Stephan, Boudaoud Saida, Seror Raphaèle, Goupille Philippe, Chanson Philippe, van der Heijde Désirée, van Gaalen Floris, Berenbaum Francis, Mariette Xavier, Briot Karine, Feydy Antoine, Claudepierre Pascal, Dieudé Philippe, Nithitham Joanne, Taylor Kimberly E, Criswell Lindsey A, Dougados Maxime, Roux Christian, Miceli-Richard Corinne
Institut Pour la Santé et la Recherche Médicale (INSERM) U1184, Université Paris-Sud 11, Le kremlin Bicêtre, France.
Service de rhumatologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin Bicêtre, France.
PLoS One. 2015 Aug 27;10(8):e0134974. doi: 10.1371/journal.pone.0134974. eCollection 2015.
To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.
The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.
Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 serum levels were higher in axial SpA patients than controls (30.03 ± 15.5 vs. 11.6 ± 4.2 pmol/L; p<0.0001). In multivariate analysis, DKK-1 serum levels were associated with male gender (p = 0.03), CRP level (p = 0.006), SOST serum level (p = 0.002) and presence of sacroiliitis on radiography (p = 0.05). Genetic association testing of 10 SNPs encompassing the DKK-1 locus failed to demonstrate a significant contribution of genetics to control of DKK-1 serum levels.
DKK-1 serum levels were increased and SOST levels were decreased among a large cohort of patients with early axial SpA compared to healthy controls. DKK-1 serum levels were mostly associated with biological inflammation and SOST serum levels.
研究符合脊柱关节炎国际评估协会（ASAS）脊柱关节炎标准的近期炎性背痛（IBP）患者的DKK-1和SOST血清水平及相关因素。
DESIR队列研究是一项前瞻性、多中心的法国队列研究，纳入708例提示轴向脊柱关节炎（AxSpA）的早期炎性背痛患者（病程>3个月且<3年）。在基线时评估DKK-1和SOST血清水平，并在符合ASAS脊柱关节炎标准的患者亚组（n = 486；68.6%）和80名健康对照者之间进行比较。
ASAS+患者的平均SOST血清水平低于健康对照者（49.21±25.9对87.8±26 pmol/L；p<0.0001）。多因素分析显示，年龄（p = 5.4×10-9）、CRP水平（p<0.0001）和血清DKK-1水平（p = 0.001）与SOST水平相关。轴向脊柱关节炎患者的平均DKK-1血清水平高于对照组（30.03±15.5对11.6±4.2 pmol/L；p<0.0001）。多因素分析显示，DKK-1血清水平与男性性别（p = 0.03）、CRP水平（p = 0.006）、SOST血清水平（p = 0.002）和X线片显示的骶髂关节炎（p = 0.05）相关。对包含DKK-1基因座的10个单核苷酸多态性（SNP）进行基因关联测试，未发现遗传学对DKK-1血清水平控制有显著贡献。
与健康对照者相比，一大群早期轴向脊柱关节炎患者的DKK-1血清水平升高，SOST水平降低。DKK-1血清水平主要与生物炎症和SOST血清水平相关。
