一种用于人类全血微量培养的简单方法及其在辐射生物剂量测定中的应用。
A Simple Method for Human Whole Blood Microcultures and Its Application in Radiation Biodosimetry.
作者信息
Yan Guo, Wen Zhang, Chaoxian Gao, Changye Hui, Xueqin Yang, Xinyue Yang, Zhimin Li
机构信息
*Shenzhen Major Occupation Disease Diagnosis and Treatment Technology Key Laboratory, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.
出版信息
Health Phys. 2015 Oct;109(4):323-6. doi: 10.1097/HP.0000000000000331.
The scoring of the cytokinesis-block micronucleus and dicentric chromosomes in human peripheral blood lymphocytes is used as a dosimeter of radiation exposure. A detailed methodology is presented for human whole blood microculture for cytogenetic analysis. The technique described yields more than sufficient numbers of mitotic lymphocytes for analyzing micronuclei and chromosome aberrations following exposure to radiation.
人外周血淋巴细胞胞质分裂阻滞微核和双着丝粒染色体的评分被用作辐射暴露的剂量计。本文介绍了用于细胞遗传学分析的人全血微量培养的详细方法。所描述的技术产生的有丝分裂淋巴细胞数量足以分析辐射暴露后的微核和染色体畸变。
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