Wang Zhenjun, Chen Shuai, Ren Jun, Wang Zhongwen
State Key Laboratory and Institute of Elemento-Organic Chemistry, Synergetic Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , 94 Weijin Road, Tianjin 300071, P.R. China.
Org Lett. 2015 Sep 4;17(17):4184-7. doi: 10.1021/acs.orglett.5b01928. Epub 2015 Aug 27.
A tandem isomerization/intramolecular [3 + 2] cross-cycloaddition (IMCC) of cyclopropane 1,1-diesters with α,β-unsaturated ketones/aldehydes under a cooperative catalysis of photo and Lewis acids has been successfully developed. This supplied a general and efficient strategy for construction of medium-sized carbocyclic (8-, 9-, and 10-membered) skeletons as well as such carbocycle-based bridged oxa-bicyclo[n.2.1] (n = 4-6) skeletons.
在光和路易斯酸的协同催化下，环丙烷1,1 - 二酯与α,β - 不饱和酮/醛的串联异构化/分子内[3 + 2]交叉环加成反应（IMCC）已成功开发。这为构建中等大小的碳环（8、9和10元）骨架以及此类基于碳环的桥连氧杂双环[n.2.1]（n = 4 - 6）骨架提供了一种通用且有效的策略。
