Liu Ya-Lin, Wang Wen-Juan, Liu Hai-Bo
Departement of Hematology, The First Affiliated Hospital of Xi'an University, Xi'an 710061, Shaanxi Province, China.
Departement of Hematology, The First Affiliated Hospital of Xi'an University, Xi'an 710061, Shaanxi Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1053-5. doi: 10.7534/j.issn.1009-2137.2015.04.029.
To explore the value of bone marrow smear and biopsy simultaneously applied to diagnosis of multiple myloma (MM).
Clinical data of 30 cases of multiple myloma were collected from our hospital in the year 2014 and analyzed retrospectively, and the results of the bone marrow smear and the simultaneous bone marrow biopsy were compared.
Hyperplasia levels in bone marrow biopsy was significantly higher than that in bone marrow smears, and the active and highly active hyperplasia of nucleated cells were observed in all the bone marrow biopsies; the myeloma cells showed a focal or diffuse distribution, the binuclear or polynuclear myeloma cells were observed in 22 patients (73%), but the detection rate of abnormal myeloma cells was 40% in bone marrow smear (P < 0.05). There was mild to moderate hyperplasia of fibrous tissue in bone marrow biopsy, and the hyperplasia degeree of fibrous tissue strongly positively correlated with the myeloma cell ratio (r = 0.412).
The bone marrow smear and aspiration biopsy can complement each other so as to reduce the misdiagnosis rate, therefore contributes to the early diaglosis and treatment.
探讨骨髓涂片与活检同步应用于多发性骨髓瘤（MM）诊断的价值。
收集我院2014年30例多发性骨髓瘤患者的临床资料进行回顾性分析，比较骨髓涂片及同步骨髓活检结果。
骨髓活检增生程度显著高于骨髓涂片，所有骨髓活检均见有核细胞呈活跃及高度活跃增生；骨髓瘤细胞呈局灶性或弥漫性分布，22例（73%）可见双核或多核骨髓瘤细胞，但骨髓涂片异常骨髓瘤细胞检出率为40%（P<0.05）。骨髓活检可见纤维组织呈轻度至中度增生，纤维组织增生程度与骨髓瘤细胞比例呈强正相关（r=0.412）。
骨髓涂片与穿刺活检可相互补充，降低误诊率，有助于早期诊断及治疗。
