[155例初诊POEMS综合征患者骨髓细胞的形态学表现]
[Morphology Manifestation of Bone Marrow Cells in 155 Newly- Diagnosed Patients with POEMS Syndrome].
作者信息
Jiang Xian-Yong, Zhao Xiao-Peng, Ge Chang-Wen, Zhou Dao-Bin, Li Jian
机构信息
Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1165-7. doi: 10.7534/j.issn.1009-2137.2015.04.050.
OBJECTIVE
To investigate the morphological manifestation of bone marrow cells in newly-diagnosed patients with POEMS syndrome.
METHODS
The bone marrow cells in 155 patients with POEMS syndrome were classified and counted by OLYMPUS BX51 microscope, and the abnormal morphology of bone marrow cells was observed.
RESULTS
The count of plasma cells with normal morphology was 83.9% (130/155), the count of plasma cells with abnormal morphology (< 5 percent) was 12.3% (19/155), the count of plasma cells with obvious abnormal morphology (> 10 percent) was 3.8% (6/155) in patients with POEMS syndrome.
CONCLUSION
The morphology of plasma cells in the most patients with the POEMS syndrome are normal, the minor patients of the POEMS syndrome have little abnormal plasma cell morphology, the extremely few patients showed obvious morphological abnormality in the bone marrow plasma cells. The higher proportion of plasma cells, the more easily and more abnormal plasma cells will be found.
目的
探讨初诊POEMS综合征患者骨髓细胞的形态学表现。
方法
采用OLYMPUS BX51显微镜对155例POEMS综合征患者的骨髓细胞进行分类计数，并观察骨髓细胞的形态异常情况。
结果
POEMS综合征患者中形态正常浆细胞计数占83.9%（130/155），形态异常（<5%）浆细胞计数占12.3%（19/155），形态明显异常（>10%）浆细胞计数占3.8%（6/155）。
结论
多数POEMS综合征患者浆细胞形态正常，少数患者浆细胞形态轻度异常，极少数患者骨髓浆细胞形态明显异常。浆细胞比例越高，越易发现异常浆细胞且异常程度越高。
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