[Ikaros在B细胞急性淋巴细胞白血病中的作用]

[Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia].

作者信息

Zhang Hai-Ying, Bai Hai

机构信息

Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Commond General Hospital, Lanzhou 730050, Gansu Province, China.

Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Commond General Hospital, Lanzhou 730050, Gansu Province, China . E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1194-8. doi: 10.7534/j.issn.1009-2137.2015.04.056.

DOI:10.7534/j.issn.1009-2137.2015.04.056

PMID:26314472

Abstract

The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor prognosis. This review briefly summarizes the available data regarding the structure and function of Ikaros, the role of Ikaros as a tumor suppressor in B-ALL, and its regulation mechanism.

摘要

伊卡罗斯（Ikaros）是一种DNA结合锌指蛋白，作为染色质重塑和基因转录的调节因子，对于调节免疫系统的发育和功能以及作为造血分化的主要调节因子起着至关重要的作用。编码伊卡罗斯的基因IKZF1的功能丧失突变在B细胞急性淋巴细胞白血病（B-ALL）中很常见，并且与预后不良相关。本文综述简要总结了关于伊卡罗斯的结构和功能、伊卡罗斯在B-ALL中作为肿瘤抑制因子的作用及其调节机制的现有数据。