胰腺癌的三重编码模型：遗传学、表观遗传学和核结构之间的相互作用
The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure.
作者信息
Lomberk Gwen A, Urrutia Raul
机构信息
Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Guggenheim 10-24A, Rochester, MN 55905, USA.
Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biophysics, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Medicine, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA.
出版信息
Surg Clin North Am. 2015 Oct;95(5):935-52. doi: 10.1016/j.suc.2015.05.011. Epub 2015 Jul 23.
Pancreatic adenocarcinoma is painful, generally incurable, and frequently lethal. The current progression model indicates that this cancer evolves by mutations and deletions in key oncogenes and tumor suppressor genes. This article describes an updated, more comprehensive model that includes concepts from the fields of epigenetics and nuclear architecture. Widespread use of next-generation sequencing for identifying genetic and epigenetic changes genome-wide will help identify and validate more and better markers for this disease. Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view.
胰腺腺癌会引发疼痛，通常无法治愈，且常常致命。当前的进展模型表明，这种癌症是通过关键癌基因和肿瘤抑制基因的突变及缺失而演变的。本文描述了一种更新的、更全面的模型，该模型纳入了表观遗传学和核结构领域的概念。广泛使用下一代测序技术在全基因组范围内鉴定遗传和表观遗传变化，将有助于识别和验证更多更好的该疾病标志物。表观遗传改变适合进行药物操控，因此这种新的综合范式将从机制和转化的角度推动该领域的发展。
Zotero 插件