Amin Amr, El-Kareem Maha Abd, Yahia Abu Baker
Department of Nuclear Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nucl Med Rev Cent East Eur. 2015;18(2):61-4. doi: 10.5603/NMR.2015.0016.
Tc-99m methylene diphosphonate [MDP] bone scan is the basis of the skeletal imaging in nuclear medicine being a highly sensitive tool for detecting bone diseases. Mechanical stimulation induced by low grade exercise or whole-body vibration appears to be advantageous regarding the maintenance and/or improvement of skeletal mass in humans. We aimed to assess the physiological influence of low grade exercise on the quality of skeletal scintigraphy using Tc-99m MDP.
Tc-99m MDP bone scan was done for 92 volunteers [Group 1; G1]. Five days later, the same subjects were re-scanned [Group 2; G2] after an exercise on treadmill for 5 minutes. Image quality was assessed using quantitative measures whereby equal regions of interest (ROI) were drawn over the femoral diaphysis, and the contralateral adductor area. The total number of counts from the bone [B] ROI and soft tissue [ST] ROI was expressed as a ratio [B:ST ratio] and a mean value for each was established.
Statistically significant difference was found between the B:ST ratio means [p = 0.001] in G1 and G2.
This study raised a physiological influence of low grade exercise on the image quality of tc-99m MDP skeletal scintigraphy by increasing MDP osseous uptake.
锝-99m亚甲基二膦酸盐[MDP]骨扫描是核医学中骨骼成像的基础，是检测骨疾病的高度敏感工具。低强度运动或全身振动引起的机械刺激似乎有利于维持和/或改善人体骨骼质量。我们旨在评估低强度运动对使用锝-99m MDP进行的骨骼闪烁显像质量的生理影响。
对92名志愿者进行锝-99m MDP骨扫描（第1组；G1）。五天后，同一批受试者在跑步机上运动5分钟后再次进行扫描（第2组；G2）。使用定量方法评估图像质量，即在股骨干和对侧内收肌区域绘制等大感兴趣区（ROI）。骨（B）ROI和软组织（ST）ROI的计数总数表示为比率[B：ST比率]，并确定每个区域的平均值。
G1组和G2组的B：ST比率平均值之间存在统计学显著差异[p = 0.001]。
本研究通过增加MDP的骨摄取量，揭示了低强度运动对锝-99m MDP骨骼闪烁显像图像质量的生理影响。
