López Sastre J, Roza Suárez M, Salinas E, Ramos Polo E, Antuña García M J, García Amorín Z
Departamento de Pediatría, Hospital General de Asturias.
An Esp Pediatr. 1989 Sep;31(3):280-5.
Based upon our previous experience on the treatment of meningococcal infections with satisfactory evolution when the fourth day of therapy was finalized and taking into account published experiences with four or less days of therapy, we realized a study on the efficacy of a four days therapy when venial meningococcal infections but of seven days when the serious ones. The results obtained were like the former ones we published concerning to death rate but having inferior number of complications. The results of our study suggest that meningococcal infections may be successfully treated according to seriousness, with a four or seven-day course of intravenous penicillin G (300,000 UI/kg/day) distributed in six "aliquots" each four hours. The possibility of a four-days therapy, not taking into account seriousness, is considered for every meningococcal infections.
基于我们之前治疗脑膜炎球菌感染的经验，即治疗第四天结束时病情进展令人满意，并考虑到已发表的关于四天或更短疗程治疗的经验，我们开展了一项研究，观察轻症脑膜炎球菌感染采用四天疗程、重症采用七天疗程治疗的疗效。获得的结果与我们之前发表的关于死亡率的结果相似，但并发症数量较少。我们的研究结果表明，脑膜炎球菌感染可根据病情严重程度成功治疗，采用静脉注射青霉素G（30万单位/千克/天），分六次“等分剂量”，每四小时一次，疗程为四天或七天。对于所有脑膜炎球菌感染，无论病情严重程度，都考虑采用四天疗程治疗的可能性。
