Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin-3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush.
作者信息
Bonetti Leandro Viçosa, Ilha Jocemar, Schneider Ana Paula Krauthein, Barbosa Silvia, Faccioni-Heuser Maria Cristina
机构信息
Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, CEP 90050-170, Porto Alegre, Rio Grande do Sul, Brazil.
出版信息
Muscle Nerve. 2016 Apr;53(4):617-25. doi: 10.1002/mus.24889. Epub 2015 Dec 29.
INTRODUCTION
Numerous rehabilitation treatments have been shown to be useful for peripheral and central restoration after (PNI).
METHODS
After sciatic nerve crush, we investigated 4 weeks of endurance training (ET) and balance and coordination training (BCT) with sciatic function index, hind-paw stride length, and spinal cord dorsal horn synaptophysin and neurotrophin-3 immunoreactivity.
RESULTS
Our results demonstrated no significant differences between the non-trained (NT), ET, and BCT groups in sciatic functional index, and in stride-length analysis, but the ET showed higher values compared with the NT group. Synaptophysin immunoreactivity was higher in the BCT group compared with the NT group, and neurotrophin-3 immunoreactivity in the BCT group was greater compared with the other groups.
CONCLUSION
BCT can positively affect spinal cord plasticity after a (PNI), and these modifications are important in the rehabilitation process.
Zotero 插件