Pintér A, Török G, Surjan A, Csik M, Börzsönyi M, Kelecsenyi Z
Ann Ist Super Sanita. 1989;25(4):577-82.
Twenty-two herbicides were studied in 67 tests for induction of DNA damage, gene mutation and chromosomal changes in vitro and in vivo. Triazine and urea-type herbicides were found to be inactive in all but one test. Of 4 thiocarbamates, molinate and vernolate caused chromosomal changes, namely increased incidence of sister chromatid exchanges and chromosomal aberrations in vitro and increased frequency of micronucleated polychromatic erythrocytes in mouse bone marrow. These compounds, however, did not cause gene mutation and only molinate gave equivocal positive result in bacterial repair test. Out of 11 miscellaneous herbicides, ethofumesate, alachlor, dichlorprop and fluorodifen proved to be positive only in one or two tests. In the light of clastogenicity of some thiocarbamates, serious consideration should be given to start animal carcinogenicity studies with these chemicals.
对22种除草剂进行了67次试验，研究其在体外和体内诱导DNA损伤、基因突变及染色体变化的情况。除一项试验外，均发现三嗪类和脲类除草剂无活性。在4种硫代氨基甲酸盐中，禾草敌和灭草猛会引起染色体变化，即在体外姐妹染色单体交换和染色体畸变的发生率增加，在小鼠骨髓中微核多染红细胞的频率增加。然而，这些化合物不会引起基因突变，只有禾草敌在细菌修复试验中给出了模棱两可的阳性结果。在11种其他除草剂中，乙氧呋草黄、甲草胺、二氯丙酸和氟乐灵仅在一两项试验中呈阳性。鉴于某些硫代氨基甲酸盐的致断裂性，应认真考虑对这些化学物质开展动物致癌性研究。
