Gontmakher V M, Sagdullaev Z Z, Zufarov A K
Arkh Anat Gistol Embriol. 1989 Nov;97(11):87-92.
As a result of comparative investigation of compensatory processes in the kidneys at various degree of their resection, the most general regularities in these processes have been revealed: an initial functional strain of renal cells and their ultrastructures, the secondary increase in hypertrophy and hyperplasia of the renal cells and their organelles. The degree of manifestation of these regular reactions directly depends on the mass of the resected part of the kidney. Subtotal resection of the kidney (80%) is an operation that gets out of the limits of the organ's compensatory possibilities. A sharp decrease, up to complete disappearance of its cellular division in 2-3 weeks after the operation is of great importance. Mechanism for development of renal insufficiency is evidently connected with absence of cellular renewal against the background of their hyperfunction and their quick worn out, that is, evidently, resulted in deficiency of renal epithelium and functional defectiveness connected with it in the remained renal mass.
通过对不同切除程度的肾脏代偿过程进行比较研究，揭示了这些过程中最普遍的规律：肾细胞及其超微结构的初始功能应激，肾细胞及其细胞器肥大和增生的继发性增加。这些规律性反应的表现程度直接取决于切除的肾脏部分的质量。肾次全切除术（80%）是一种超出器官代偿可能性范围的手术。术后2 - 3周其细胞分裂急剧减少直至完全消失，这一点非常重要。肾功能不全的发生机制显然与在肾细胞功能亢进及其快速耗竭的背景下缺乏细胞更新有关，也就是说，显然导致了肾上皮细胞的缺乏以及与之相关的剩余肾组织中的功能缺陷。
