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腺苷信号在疾病与治疗中的有益和有害作用。

Beneficial and detrimental role of adenosine signaling in diseases and therapy.

作者信息

Liu Hong, Xia Yang

机构信息

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas; Graduate School of Biomedical Science, University of Texas Health Science Center at Houston, Houston, Texas; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China; and.

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas; Graduate School of Biomedical Science, University of Texas Health Science Center at Houston, Houston, Texas; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China

出版信息

J Appl Physiol (1985). 2015 Nov 15;119(10):1173-82. doi: 10.1152/japplphysiol.00350.2015. Epub 2015 Aug 27.

Abstract

Adenosine is a major signaling nucleoside that orchestrates cellular and tissue adaptation under energy depletion and ischemic/hypoxic conditions by activation of four G protein-coupled receptors (GPCR). The regulation and generation of extracellular adenosine in response to stress are critical in tissue protection. Both mouse and human studies reported that extracellular adenosine signaling plays a beneficial role during acute states. However, prolonged excess extracellular adenosine is detrimental and contributes to the development and progression of various chronic diseases. In recent years, substantial progress has been made to understand the role of adenosine signaling in different conditions and to clarify its significance during the course of disease progression in various organs. These efforts have and will identify potential therapeutic possibilities for protection of tissue injury at acute stage by upregulation of adenosine signaling or attenuation of chronic disease progression by downregulation of adenosine signaling. This review is to summarize current progress and the importance of adenosine signaling in different disease stages and its potential therapeutic effects.

摘要

腺苷是一种主要的信号核苷,在能量耗竭和缺血/缺氧条件下,通过激活四种G蛋白偶联受体(GPCR)来协调细胞和组织的适应性。应激反应时细胞外腺苷的调节和生成对组织保护至关重要。小鼠和人类研究均报道,细胞外腺苷信号在急性期发挥有益作用。然而,细胞外腺苷长期过量是有害的,并会促进各种慢性疾病的发生和发展。近年来,在了解腺苷信号在不同条件下的作用以及阐明其在各种器官疾病进展过程中的意义方面取得了重大进展。这些努力已经并将确定通过上调腺苷信号来保护急性期组织损伤或通过下调腺苷信号来减轻慢性疾病进展的潜在治疗可能性。本综述旨在总结腺苷信号在不同疾病阶段的当前进展、重要性及其潜在治疗作用。

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