KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITÄT MÜNCHEN.
Blood. 2015 Aug 27;126(9):1051-2. doi: 10.1182/blood-2015-07-653402.
In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of the endoplasmic reticulum–localized O-acyltransferase porcupine (PORCN), which is necessary for acylation of Wnts in the endoplasmic reticulum, enabling their secretion and binding to the frizzled receptors. Unexpectedly, the absence of secreted Wnt factors does not have major effects on steady-state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic stem cells.
在本期《Blood》中，Kabiri 及其同事报道了内质网定位的酰基转移酶刺猬（PORCN）的造血细胞缺失，PORCN 对于 Wnt 在内质网中的酰化是必需的，从而使其能够分泌并与 frizzled 受体结合。出乎意料的是，分泌的 Wnt 因子的缺失对体内稳态造血或对 Wnt 缺陷造血干细胞的长期重编程活性没有重大影响。
