Fahrni Jennifer, Husmann Marc, Gretener Silvia B, Keo Hong H
Division of Angiology, Medical University Clinic, Kantonsspital Aarau AG, Aarau, Switzerland.
Clinic for Angiology, University Hospital, University of Zurich, Zürich, Switzerland.
Vasc Health Risk Manag. 2015 Aug 17;11:451-9. doi: 10.2147/VHRM.S83718. eCollection 2015.
Recurrent venous thromboembolism (VTE) is associated with increased morbidity and mortality. This risk is lowered by anticoagulation, with a large effect in the initial phase following the venous thromboembolic event, and with a smaller effect in terms of secondary prevention of recurrence when extended anticoagulation is performed. On the other hand, extended anticoagulation is associated with an increased risk of major bleeding and thus leads to morbidity and mortality. Therefore, it is necessary to assess the risk of recurrence for VTE on an individual basis, and a recommendation for secondary prophylaxis should be specifically based on risk calculation of recurrence of VTE and bleeding. In this review, we provide a comprehensive summary of relevant risk factors for recurrent VTE and a practical approach for assessing the risk of recurrence in daily practice.
复发性静脉血栓栓塞症（VTE）与发病率和死亡率的增加相关。抗凝治疗可降低这种风险，在静脉血栓栓塞事件后的初始阶段效果显著，而在进行延长抗凝治疗以预防复发方面效果较小。另一方面，延长抗凝治疗与大出血风险增加相关，从而导致发病和死亡。因此，有必要对个体的VTE复发风险进行评估，二级预防的建议应具体基于VTE复发和出血风险的计算。在本综述中，我们全面总结了复发性VTE的相关危险因素以及在日常实践中评估复发风险的实用方法。
