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2015年世界免疫肿瘤学大会亮点:新靶点、创新药物及先进技术——一种成功策略?

Highlights from the 2015 WIN Symposium: novel targets, innovative agents, and advanced technologies-a WINning strategy?

作者信息

Schilsky Richard L

机构信息

American Society of Clinical Oncology, Alexandria, Virginia 22314, USA.

出版信息

Ecancermedicalscience. 2015 Aug 13;9:564. doi: 10.3332/ecancer.2015.564. eCollection 2015.

DOI:10.3332/ecancer.2015.564
PMID:26316885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4544575/
Abstract

The worldwide innovative networking (WIN) consortium comprises a global alliance of 28 academic and clinical cancer centres, 11 pharmaceutical and technology companies and five charitable or health payer organisations. Since its inception the consortium has striven to provide a forum for all of its members to network, share information and experience, and perform clinical trials with the overarching goal of advancing the care of patients with cancer through the use of precision medicine. The annual 2-day WIN Symposium is the most visible output of the consortium and provides an opportunity for around 400 experts and other delegates to meet and discuss the latest research and initiatives in personalised cancer medicine. The seventh WIN Symposium, held in Paris, France, 29-30 June 2015, consisted of nine plenary and eight poster sessions that covered the overarching theme of novel targets, innovative agents, and advanced technologies being a winning strategy. Highlights included discussions of immune mechanisms and ways to target the cancer immunome and systems biology approaches to supporting personalised cancer. The latest data from the BATTLE-2 and WINther trials were discussed, and round table discussions were held that focused on how best to design the next generation of clinical trials, which included SPRING, SUMMER, and BOOSTER being initiated by the WIN Consortium.

摘要

全球创新网络(WIN)联盟由28个学术和临床癌症中心、11家制药和科技公司以及5个慈善或医疗支付机构组成的全球联盟。自成立以来,该联盟一直致力于为所有成员提供一个交流网络、分享信息和经验以及开展临床试验的平台,其总体目标是通过精准医疗改善癌症患者的治疗。为期两天的年度WIN研讨会是该联盟最引人注目的成果,为约400名专家和其他代表提供了一个会面并讨论个性化癌症医学最新研究和倡议的机会。2015年6月29日至30日在法国巴黎举行的第七届WIN研讨会包括9场全会和8场海报展示,涵盖了新型靶点、创新药物和先进技术作为制胜策略这一总体主题。亮点包括对免疫机制以及针对癌症免疫组的方法和支持个性化癌症的系统生物学方法的讨论。会上讨论了BATTLE - 2和WINther试验的最新数据,并举行了圆桌讨论,重点是如何最好地设计下一代临床试验,其中包括WIN联盟发起的SPRING、SUMMER和BOOSTER试验。

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本文引用的文献

1
A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer.一种用于选择非小细胞肺癌靶向治疗组合的简化介入映射系统(SIMS)。
Oncotarget. 2015 Jun 10;6(16):14139-52. doi: 10.18632/oncotarget.3741.
2
Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial.启动和开展个性化癌症治疗试验的挑战:来自全球创新网络(WIN)联盟试验WINTHER的观点
Ann Oncol. 2015 Aug;26(8):1791-8. doi: 10.1093/annonc/mdv191. Epub 2015 Apr 23.
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The BATTLE trial: personalizing therapy for lung cancer.BATTLE 试验:为肺癌患者实施个体化治疗。
Cancer Discov. 2011 Jun;1(1):44-53. doi: 10.1158/2159-8274.CD-10-0010. Epub 2011 Jun 1.