Tomita Masaki, Ayabe Takanori, Shimizu Tetsuya, Nakamura Kunihide
Department of Surgery II, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan.
Lung Cancer Int. 2012;2012:463520. doi: 10.1155/2012/463520. Epub 2012 Nov 26.
The association between hypocholesterolemia and lung cancer risk has been confirmed in some studies. The purpose of the study was to determine whether preoperative hypocholesterolemia (below normal range) is a prognostic factor for survival after nonsmall cell lung cancer (NSCLC) resection. Two hundred and sixty-two consecutive cases of resected NSCLC with a followup period for more than 5 years were reviewed retrospectively. In our results, there were only 13/262 patients having hypocholesterolemia. A significant association was observed between preoperative hypocholesterolemia and patients' survival. However, we failed to find the prognostic significance of preoperative hypocholesterolemia by univariate analysis. No statistical differences were also found by the comparison between 5-year survivors and the others. Our data indicates a trend toward an association between preoperative hypocholesterolemia and poorer survival in NSCLC; however, it did not reach statistical significance.
一些研究已证实低胆固醇血症与肺癌风险之间的关联。本研究的目的是确定术前低胆固醇血症（低于正常范围）是否是非小细胞肺癌（NSCLC）切除术后生存的预后因素。回顾性分析了262例连续切除的NSCLC患者，随访期超过5年。在我们的研究结果中，262例患者中仅有13例存在低胆固醇血症。术前低胆固醇血症与患者生存之间存在显著关联。然而，单因素分析未发现术前低胆固醇血症的预后意义。5年生存者与其他患者之间的比较也未发现统计学差异。我们的数据表明术前低胆固醇血症与NSCLC患者较差的生存率之间存在关联趋势；然而，未达到统计学意义。
