Amin Waqas, Parwani Anil V, Melamed Jonathan, Flores Raja, Pennathur Arjun, Valdivieso Federico, Whelan Nancy B, Landreneau Rodeny, Luketich James, Feldman Michael, Pass Harvey I, Becich Michael J
Department of Biomedical Informatics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Lung Cancer Int. 2013;2013:765748. doi: 10.1155/2013/765748. Epub 2013 Sep 18.
The National Mesothelioma Virtual Bank (NMVB), developed six years ago, gathers clinically annotated human mesothelioma specimens for basic and clinical science research. During this period, this resource has greatly increased its collection of specimens by expanding the number of contributing academic health centers including New York University, University of Pennsylvania, University of Pittsburgh Medical Center, and Mount Sinai School of Medicine. Marketing efforts at both national and international annual conferences increase awareness and availability of the mesothelioma specimens at no cost to approved investigators, who query the web-based NMVB database for cumulative and appropriate patient clinicopathological information on the specimens. The data disclosure and specimen distribution protocols are tightly regulated to maintain compliance with participating institutions' IRB and regulatory committee reviews. The NMVB currently has over 1120 annotated cases available for researchers, including paraffin embedded tissues, fresh frozen tissue, tissue microarrays (TMA), blood samples, and genomic DNA. In addition, the resource offers expertise and assistance for collaborative research. Furthermore, in the last six years, the resource has provided hundreds of specimens to the research community. The investigators can request specimens and/or data by submitting a Letter of Intent (LOI) that is evaluated by NMVB research evaluation panel (REP).
国家间皮瘤虚拟库（NMVB）于六年前建立，收集经过临床注释的人间皮瘤标本用于基础和临床科学研究。在此期间，该资源通过增加包括纽约大学、宾夕法尼亚大学、匹兹堡大学医学中心和西奈山医学院在内的学术健康中心的数量，极大地扩充了标本收集量。在国内和国际年会上的推广工作提高了间皮瘤标本的知名度和可获取性，这些标本免费提供给经批准的研究人员，他们可通过基于网络的NMVB数据库查询标本累积的和合适的患者临床病理信息。数据披露和标本分发协议受到严格监管，以确保符合参与机构的机构审查委员会（IRB）和监管委员会的审查要求。NMVB目前有超过1120例经过注释的病例可供研究人员使用，包括石蜡包埋组织、新鲜冷冻组织、组织微阵列（TMA）、血液样本和基因组DNA。此外，该资源还为合作研究提供专业知识和协助。此外，在过去六年中，该资源已向研究界提供了数百份标本。研究人员可通过提交意向书（LOI）来请求获取标本和/或数据，该意向书将由NMVB研究评估小组（REP）进行评估。
