Singh Huidrom Suraj, Salam Kabita, Saraswathy Kallur Nava
Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi 110007, India ; Department of Anthropology and Tribal Development, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495009, India.
Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi 110007, India ; The INCLEN Trust International, Okhla Industrial Area, Phase I, New Delhi 110020, India.
J Biomark. 2014;2014:310241. doi: 10.1155/2014/310241. Epub 2014 Oct 1.
Chronic alcohol consumption is reported to be associated with increase in plasma homocysteine levels which is further influenced by the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene. The present study aims to understand the extent of the MTHFR C677T polymorphism in alcohol dependent (AD) cases of Meiteis of Manipur, a Mendelian population of India. MTHFR C677T polymorphism was screened in 313 controls and 139 alcohol dependent (AD) cases who all met DSM-IV criteria for alcohol dependence. Both AD cases and controls were unrelated up to 1st cousin. Among the control group, different drinking patterns like abstainer/nondrinkers (NDs), occasional drinkers (ODs), and moderate drinkers (MDs) are included. Both the groups were found to be in Hardy-Weinberg equilibrium (P > 0.05). Genotypic and allelic frequency distribution of MTHFR C677T polymorphism did not differ significantly between AD cases and controls (P > 0.05). However, individuals carrying mutant (T) allele show more than 1-fold increased risk for AD though not significant (OR = 1.43; 95% CI 0.41-5.01, P > 0.05). In conclusion, MTHFR C677T polymorphism is not found to be risk marker for AD in present studied population. However, higher prevalence of the mutant T allele may exacerbate deleterious health risk in future especially among alcohol drinkers.
据报道，长期饮酒与血浆同型半胱氨酸水平升高有关，而亚甲基四氢叶酸还原酶（MTHFR）基因的多态性会进一步影响该水平。本研究旨在了解印度孟德尔人群曼尼普尔梅泰族酒精依赖（AD）病例中MTHFR C677T多态性的程度。对313名对照者和139名酒精依赖（AD）病例进行了MTHFR C677T多态性筛查，这些病例均符合酒精依赖的DSM-IV标准。AD病例和对照者均无一级表亲以内的亲缘关系。在对照组中，纳入了不同的饮酒模式，如戒酒者/不饮酒者（NDs）、偶尔饮酒者（ODs）和适度饮酒者（MDs）。两组均处于哈迪-温伯格平衡（P>0.05）。AD病例和对照者之间MTHFR C677T多态性的基因型和等位基因频率分布无显著差异（P>0.05）。然而，携带突变（T）等位基因的个体患AD的风险增加了1倍多，尽管不显著（OR = 1.43；95% CI 0.41 - 5.01，P>0.05）。总之，在本研究人群中，未发现MTHFR C677T多态性是AD的风险标志物。然而，突变T等位基因的较高患病率可能会在未来加剧有害健康风险，尤其是在饮酒者中。
