一名阿尔茨海默病患者出现美金刚诱发的肌阵挛
Memantine-induced Myoclonus in a Patient with Alzheimer Disease.
作者信息
Murgai Aditya A, LeDoux Mark S
机构信息
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2015 Aug 14;5:337. doi: 10.7916/D8ZG6RD9. eCollection 2015.
BACKGROUND
Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment.
CASE REPORT
Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was generalized (proximal limbs and trunk), present at rest and with action, and stimulus sensitive. A structured evaluation with the Unified Myoclonus Rating Scale showed that the myoclonus had no significant effect on functional capacity. After discontinuation of memantine, myoclonus slowly resolved over the course of several weeks.
DISCUSSION
Memantine may cause myoclonus in susceptible individuals.
背景
肌阵挛可能是多种神经退行性疾病的临床表现，也是用于治疗这些疾病的药物的不良反应。
病例报告
在此，我们报告了1例阿尔茨海默病患者出现美金刚诱发的肌阵挛。我们患者出现的肌阵挛为全身性（近端肢体和躯干），在休息和活动时均有，且对刺激敏感。采用统一肌阵挛评定量表进行的结构化评估显示，该肌阵挛对功能能力无显著影响。停用美金刚后，肌阵挛在数周内逐渐缓解。
讨论
美金刚可能会使易感个体发生肌阵挛。
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