Xu Feng, Lei Chao, Yan Lei, Tu Jingxuan, Li Gaoqiang
Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi, People's Republic of China.
Chirality. 2015 Oct;27(10):761-5. doi: 10.1002/chir.22498. Epub 2015 Aug 28.
Four novel chiral amino alcohols were synthesized from D-(+)-camphor and utilized as ligands in a Cu(I)-catalyzed asymmetric Henry reaction. The reactions were carried out under mild conditions with excellent enantioselectivities and moderate yields without the exclusion of air or moisture. The highest enantioselectivity was observed up to 94% enantiomeric excess (ee) with ligand in toluene at room temperature.
从 D-(+)-樟脑合成了四种新型手性氨基醇，并将其用作铜（I）催化的不对称亨利反应中的配体。反应在温和条件下进行，对映选择性优异，产率适中，无需排除空气或水分。在室温下，使用甲苯中的配体时，观察到最高对映选择性高达 94%对映体过量（ee）。
