高效液相色谱法测定一种电鱼（彼得氏裸臀鱼）中的阿扑吗啡。
HPLC-determination of apomorphine in a mormyrid fish, gnathonemus petersii.
作者信息
Noe A, Kunze P
机构信息
Biologisches Institut der Universität Stuttgart, Abteilung Tierphysiologie, Bundesrepublik Deutschland.
出版信息
Z Naturforsch C J Biosci. 1989 Nov-Dec;44(11-12):917-9. doi: 10.1515/znc-1989-11-1207.
PMID:2631732
Abstract
Uptake of apomorphine and elimination kinetics in brain and muscle tissue of the weakly electric fish Gnathonemus petersii (Mormyridae) was determined by HPLC. 20 min exposure of the fish to apomorphine in the aquarium water (0.4 mg/l) resulted in a concentration factor of 1.09 for brain and 0.55 for muscle tissue. Elimination from brain tissue can be described with first order kinetics (t1/2 = 2.4 h).
摘要
通过高效液相色谱法测定了弱电鱼彼得氏裸臀鱼（裸臀鱼科）脑和肌肉组织中阿扑吗啡的摄取及消除动力学。将鱼置于水族箱水中（0.4毫克/升）的阿扑吗啡中暴露20分钟后，脑的浓度系数为1.09，肌肉组织的浓度系数为0.55。脑组织中的消除可用一级动力学描述（半衰期 = 2.4小时）。
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