Vogt K, Hahn H
Institut für Medizinische Mikrobiologie der Freien Universität, Berlin.
Zentralbl Bakteriol. 1989 Dec;272(2):225-30. doi: 10.1016/s0934-8840(89)80011-8.
A combination of ciprofloxacin and fosfomycin was evaluated for synergism employing time-kill experiments. A total of 59 clinical isolates of gram-negative bacteria was examined. All organisms were moderately sensitive or resistant to ciprofloxacin; 72.9% also showed moderate sensitivity or resistance to fosfomycin. After 24 h, synergism was seen in 22% of the strains, i.e. less than reported by other authors. There was no correlation between synergistic action and sensitivity to ciprofloxacin and fosfomycin, respectively.
采用时间杀菌实验评估环丙沙星和磷霉素联合使用的协同作用。共检测了59株革兰氏阴性菌临床分离株。所有菌株对环丙沙星均为中度敏感或耐药；72.9%的菌株对磷霉素也表现出中度敏感或耐药。24小时后，22%的菌株出现协同作用，即低于其他作者报道的比例。协同作用与对环丙沙星和磷霉素的敏感性之间分别无相关性。
