增强子与启动子之间的结构和功能共性
Architectural and Functional Commonalities between Enhancers and Promoters.
作者信息
Kim Tae-Kyung, Shiekhattar Ramin
机构信息
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Department of Human Genetics, Biomedical Research Building, Room 719, 1501 NW 10(th) Avenue, Miami, FL 33136, USA.
出版信息
Cell. 2015 Aug 27;162(5):948-59. doi: 10.1016/j.cell.2015.08.008.
Abstract
With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.
摘要
随着全基因组调控转录研究的激增，传统的增强子和启动子定义显然需要重新审视。现在可以根据这些调控元件的局部和区域结构、其调控成分（包括组蛋白修饰和相关结合因子）以及它们对转录的功能贡献来对其进行表征。本综述讨论了转录调控机制中启动子和增强子之间的统一主题。
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