Guo Lina, Peng Yushuai, Zhao Can, Yang Xin, Liu Lijia, Wang Rufeng
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
Biomed Chromatogr. 2016 Apr;30(4):612-7. doi: 10.1002/bmc.3604. Epub 2015 Sep 21.
The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis, was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo, and then the latter was eliminated slowly. In addition, the simulant in vitro gastrointestinal transformation experiments demonstrated that the basic enteral environment and intestinal bacterial flora also contributed to the metabolism of tecomin to veratric acid.
对来自金莲花花朵的一种潜在生物活性化合物——金莲花素的药代动力学进行了研究。结果表明，该化合物在体内易于吸收，并迅速代谢为藜芦酸，然后后者缓慢消除。此外，体外模拟胃肠道转化实验表明，肠道碱性环境和肠道菌群也有助于金莲花素代谢为藜芦酸。
