Emami Saeed, Dadashpour Sakineh
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Eur J Med Chem. 2015 Sep 18;102:611-30. doi: 10.1016/j.ejmech.2015.08.033. Epub 2015 Aug 17.
Cancer is one of the leading health hazards and the prominent cause of death in the world. A number of anticancer agents are currently in clinical practice and used for treatment of various kinds of cancers. There is no doubt that the existing arsenal of anticancer agents is insufficient due to the high incidence of side effects and multidrug resistance. In the efforts to develop suitable anticancer drugs, medicinal chemists have focused on coumarin derivatives. Coumarin is a naturally occurring compound and a versatile synthetic scaffold possessing wide spectrum of biological effects including potential anticancer activity. This review article covers the current developments of coumarin-based anticancer agents and also discusses the structure-activity relationship of the most potent compounds.
癌症是全球主要的健康危害之一，也是主要的死亡原因。目前有多种抗癌药物应用于临床实践，用于治疗各类癌症。毫无疑问，由于副作用高发和多药耐药性，现有的抗癌药物储备并不充足。在研发合适抗癌药物的过程中，药物化学家们将重点放在了香豆素衍生物上。香豆素是一种天然存在的化合物，也是一种多功能的合成骨架，具有广泛的生物学效应，包括潜在的抗癌活性。这篇综述文章涵盖了基于香豆素的抗癌药物的当前进展，并讨论了最有效化合物的构效关系。
