Cavusoglu Erdal, Marmur Jonathan D, Yanamadala Sunitha, Chopra Vineet, Hegde Sudhanva, Nazli Anila, Singh Kamal Preet, Zhang Ming, Eng Calvin
Division of Cardiology, Department of Medicine, Bronx Veterans Affairs Medical Center, Bronx, NY, USA; Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Atherosclerosis. 2015 Oct;242(2):589-94. doi: 10.1016/j.atherosclerosis.2015.08.022. Epub 2015 Aug 17.
To investigate the long-term prognostic significance of baseline plasma IL-8 levels in a group of well-characterized male patients presenting with acute coronary syndrome.
IL-8 is a cytokine that has been implicated in the pathogenesis of atherosclerosis and acute coronary syndrome. Elevated plasma levels have been reported in patients with acute coronary syndrome.
Baseline plasma IL-8 levels were measured in 180 male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for the development of all-cause mortality for 5 years.
In a multivariate model that included a wide variety of baseline clinical, laboratory and angiographic parameters in the selection process, baseline plasma IL-8 levels (analyzed as a continuous variable) emerged as a significant predictor of all-cause mortality at 5 years (HR, 1.43; 95% CI, 1.08-1.88; p = 0.0123). Furthermore, in 3 additional multivariate models that also included in the selection process a number of contemporary biomarkers with established prognostic efficacy in ACS (i.e., NT-proBNP, hs-CRP, hemoglobin and RDW), IL-8 remained an independent predictor of all-cause mortality at 5 years.
Elevated baseline plasma levels of IL-8 are associated with an increased risk of long-term all-cause mortality in patients with acute coronary syndrome. Furthermore, this association is independent of a variety of clinical, laboratory and angiographic variables, including contemporary biomarkers with established prognostic efficacy in acute coronary syndrome.
探讨基线血浆白细胞介素-8（IL-8）水平对一组特征明确的急性冠状动脉综合征男性患者的长期预后意义。
IL-8是一种细胞因子，与动脉粥样硬化和急性冠状动脉综合征的发病机制有关。急性冠状动脉综合征患者血浆水平升高已有报道。
对180例因急性冠状动脉综合征接受冠状动脉造影的男性患者测定基线血浆IL-8水平，并对全因死亡率的发生情况进行5年的前瞻性随访。
在一个多变量模型中，该模型在选择过程中纳入了各种基线临床、实验室和血管造影参数，基线血浆IL-8水平（作为连续变量分析）成为5年全因死亡率的显著预测因子（HR，1.43；95%CI，1.08-1.88；p = 0.0123）。此外，在另外3个多变量模型中，这些模型在选择过程中还纳入了一些在急性冠状动脉综合征（ACS）中具有既定预后疗效的当代生物标志物（即N末端脑钠肽前体、高敏C反应蛋白、血红蛋白和红细胞分布宽度），IL-8仍然是5年全因死亡率的独立预测因子。
急性冠状动脉综合征患者基线血浆IL-8水平升高与长期全因死亡风险增加相关。此外，这种关联独立于各种临床、实验室和血管造影变量，包括在急性冠状动脉综合征中具有既定预后疗效的当代生物标志物。
