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Retrocyclins neutralize bacterial toxins by potentiating their unfolding.反转录环蛋白通过增强细菌毒素的解折叠作用来中和它们。
Biochem J. 2015 Apr 15;467(2):311-20. doi: 10.1042/BJ20150049.
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Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.人类防御素可促进细菌蛋白毒素热力学不稳定区域的局部解折叠。
Immunity. 2014 Nov 20;41(5):709-21. doi: 10.1016/j.immuni.2014.10.018. Epub 2014 Nov 5.
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Thermodynamic properties of the effector domains of MARTX toxins suggest their unfolding for translocation across the host membrane.MARTX毒素效应结构域的热力学性质表明，它们会展开以便穿过宿主细胞膜进行转运。
Mol Microbiol. 2014 Jun;92(5):1056-71. doi: 10.1111/mmi.12615. Epub 2014 May 2.
4
Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin.人α-防御素抑制 HIV-1 进入的多方面机制。
J Biol Chem. 2012 Aug 17;287(34):28821-38. doi: 10.1074/jbc.M112.375949. Epub 2012 Jun 25.
5
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.人α-防御素 6 通过自组装肽纳米网促进黏膜固有免疫。
Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21.
6
α-Defensins in human innate immunity.α-防御素在人体先天免疫中的作用。
Immunol Rev. 2012 Jan;245(1):84-112. doi: 10.1111/j.1600-065X.2011.01082.x.
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Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.人类α-防御素可中和炭疽致死毒素并预防其致命后果。
Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4830-5. doi: 10.1073/pnas.0500508102. Epub 2005 Mar 16.

Defensins versus pathogens: an unfolding story.

作者信息

Kudryashova Elena, Lu Wuyuan, Kudryashov Dmitri S

机构信息

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.

Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.

出版信息

Oncotarget. 2015 Oct 6;6(30):28533-4. doi: 10.18632/oncotarget.5109.

DOI:10.18632/oncotarget.5109
PMID:26318168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4745673/
Abstract
摘要