神经调节蛋白1通过增加γ-氨基丁酸能传递，经由ErbB4受体保护免受缺血性脑损伤。
Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission.
作者信息
Guan Y-F, Wu C-Y, Fang Y-Y, Zeng Y-N, Luo Z-Y, Li S-J, Li X-W, Zhu X-H, Mei L, Gao T-M
机构信息
State Key Laboratory of Organ Failure Research, Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
State Key Laboratory of Organ Failure Research, Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Bayi Brain Hospital, The Military General Hospital of Beijing PLA, Beijing 100700, China.
出版信息
Neuroscience. 2015 Oct 29;307:151-9. doi: 10.1016/j.neuroscience.2015.08.047. Epub 2015 Aug 28.
Identifying novel neuroprotectants that can halt or even reverse the effects of stroke is of interest to both clinicians and scientists. Neuregulin 1 (NRG1) is an effective neuroprotectant, but its molecular mechanisms are largely unclear. In this study, NRG1 rescued cortical neurons from oxygen-glucose deprivation (OGD) model, but the effect was blocked by neutralizing NRG1 and ErbB4 inhibition. In addition, γ-Aminobutyric acid (GABA) receptor agonists had no synergistic effect with NRG1, and the neuroprotective effect of NRG1 against OGD was partly blocked by GABA receptor antagonists. Importantly, NRG1 neuroprotection against brain ischemia was abolished in the mice with specific deletion of ErbB4 in parvalbumin (PV)-positive interneurons. In summary, NRG1 protects against ischemic brain injury via ErbB4 receptors by enhancing GABAergic transmission.
确定能够阻止甚至逆转中风影响的新型神经保护剂是临床医生和科学家都感兴趣的事情。神经调节蛋白1（NRG1）是一种有效的神经保护剂，但其分子机制在很大程度上尚不清楚。在本研究中，NRG1可从氧-葡萄糖剥夺（OGD）模型中挽救皮质神经元，但该效应被中和NRG1和抑制ErbB4所阻断。此外，γ-氨基丁酸（GABA）受体激动剂与NRG1没有协同作用，并且GABA受体拮抗剂部分阻断了NRG1对OGD的神经保护作用。重要的是，在小白蛋白（PV）阳性中间神经元中特异性缺失ErbB4的小鼠中，NRG1对脑缺血的神经保护作用被消除。总之，NRG1通过增强GABA能传递，经由ErbB4受体保护免受缺血性脑损伤。
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