P2X7受体在组织纤维化中的作用：简要综述
The role of P2X7 receptors in tissue fibrosis: a brief review.
作者信息
Gentile Daniela, Natale Mariarita, Lazzerini Pietro Enea, Capecchi Pier Leopoldo, Laghi-Pasini Franco
机构信息
Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
出版信息
Purinergic Signal. 2015 Dec;11(4):435-40. doi: 10.1007/s11302-015-9466-3. Epub 2015 Aug 29.
Abstract
Many previous studies have demonstrated that P2X(7) receptors (P2X(7)Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X(7)R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X(7)R and summarize the current knowledge about the putative role of the P2X(7)R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.
摘要
许多先前的研究表明，P2X(7)受体（P2X(7)Rs）在不同的病理条件下具有多效性功能，可能是一系列疾病治疗的新靶点。特别是，最近的研究探讨了P2X(7)R在纤维化中的作用，纤维化是大多数慢性炎症性疾病的病理结果。这篇综述的目的是讨论P2X(7)R的生物学特性，并总结目前关于P2X(7)R在引发肺、肾、肝、胰腺和心脏等多种器官纤维化中假定作用的认识。
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