Khouri Leila, Nelken Israel
Edmond and Lily Safra Center for Brain Sciences and the Department of Neuroscience, The Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, 9190401 Jerusalem, Israel.
Edmond and Lily Safra Center for Brain Sciences and the Department of Neuroscience, The Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, 9190401 Jerusalem, Israel.
Curr Opin Neurobiol. 2015 Dec;35:142-7. doi: 10.1016/j.conb.2015.08.003. Epub 2015 Aug 25.
Sensory input is inherently dynamic and redundant. Humans and animals alike show a remarkable ability to extract regularities from the sensory scene and dynamically update their responses to the environment. This type of short-term plasticity occurs on time scales ranging from seconds to minutes (and possibly longer). Mismatch Negativity (a component of the human event-related potentials, MMN) and Stimulus Specific Adaptation (a single-neuron analogue, SSA) are two examples of this form of short-term plasticity. Conceptually, both are thought to express a form of surprise and to represent predictive processing. MMN and SSA therefore provide us with handles for investigating this important time scale of short-term plasticity.
感觉输入本质上是动态且冗余的。人类和动物都表现出非凡的能力，能够从感觉场景中提取规律，并动态更新它们对环境的反应。这种短期可塑性发生在从几秒到几分钟（甚至可能更长）的时间尺度上。失匹配负波（人类事件相关电位的一个成分，MMN）和刺激特异性适应（单个神经元类似物，SSA）是这种短期可塑性形式的两个例子。从概念上讲，两者都被认为表达了一种惊讶形式，并代表预测性处理。因此，MMN和SSA为我们研究短期可塑性这一重要时间尺度提供了途径。
