腹主动脉-腔静脉分流大鼠肺静脉心肌中自律性的表现

Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt.

作者信息

Hamaguchi Shogo, Tsuneoka Yayoi, Tanaka Ayumi, Irie Masahiko, Tsuruta Masato, Nakayama Takahiro, Namekata Iyuki, Nada Mizuki, Aimoto Megumi, Takahara Akira, Tanaka Hikaru

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan; Laboratory of Pharmacology, Faculty of Pharmaceutical Science, Tokyo University of Sciences, Noda, Chiba 278-8510, Japan.

出版信息

J Pharmacol Sci. 2015 Aug;128(4):212-5. doi: 10.1016/j.jphs.2015.07.041. Epub 2015 Aug 10.

DOI:10.1016/j.jphs.2015.07.041

PMID:26318676

Abstract

Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca(2+). The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.

摘要

在大鼠中研究了腹主动脉-腔静脉分流术（AVS）对肺静脉心肌自律性的影响。在三分之一的AVS大鼠分离的肺静脉标本中观察到自发电活动，而在假手术大鼠的标本中几乎未观察到；该活动可被替他平诱导，并被卡巴胆碱或细胞内Ca(2+)螯合所抑制。与假手术大鼠相比，AVS大鼠诱发的动作电位静息膜电位较负，动作电位时程较长。这些结果表明，大鼠肺静脉心肌的自律性在慢性容量超负荷情况下表现出来。