Notterman Daniel A, Mitchell Colter
Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Institute of Social Research, University of Michigan-Ann Arbor, 426 Thompson Street, 2264 ISR, Ann Arbor, MI 48106, USA.
Pediatr Clin North Am. 2015 Oct;62(5):1227-40. doi: 10.1016/j.pcl.2015.05.012.
Recently, a new research agenda emphasizing interactions between social factors and health has emerged. The term social determinant of health often refers to any nonmedical factor directly influencing health. Health across the life span is strongly and adversely affected by social disadvantage. Research in epigenetics indicates that alterations in DNA methylation may provide a causal link between social adversity and health disparity. Likewise, accelerated loss of telomeres is correlated with chronic stress. Research is still required to develop an understanding of the role of epigenetics and perturbed telomere function in linking social adversity with health outcome.
最近，一个强调社会因素与健康之间相互作用的新研究议程出现了。健康的社会决定因素这一术语通常指直接影响健康的任何非医学因素。社会劣势对整个生命周期的健康有强烈且不利的影响。表观遗传学研究表明，DNA甲基化的改变可能为社会逆境与健康差距之间提供因果联系。同样，端粒加速缩短与慢性应激相关。仍需要开展研究以了解表观遗传学和端粒功能紊乱在将社会逆境与健康结果联系起来方面所起的作用。
