新型基于曲酸的非天然α-氨基酸衍生物的合成
Synthesis of new kojic acid based unnatural α-amino acid derivatives.
作者信息
Balakrishna C, Payili Nagaraju, Yennam Satyanarayana, Uma Devi P, Behera Manoranjan
机构信息
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India; Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India.
出版信息
Bioorg Med Chem Lett. 2015 Nov 1;25(21):4753-4756. doi: 10.1016/j.bmcl.2015.07.099. Epub 2015 Aug 7.
An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the first synthesis of C-linked kojic acid-amino acid conjugate where kojic acid is directly linked to amino acid through a C-C bond.
已描述了一种通过甘氨酸席夫碱与溴代曲酸进行烷基化反应制备基于曲酸的α-氨基酸衍生物的有效方法。使用该方法，已制备了单烷基化和二烷基化的曲酸-氨基酸共轭物。这是首次合成C-连接的曲酸-氨基酸共轭物，其中曲酸通过C-C键直接与氨基酸相连。
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