McNulty James, Krishnamoorthy Venkatesan, Amoroso Dino, Moser Michael
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4M1, Canada.
Cytec Canada Inc, 9061 Garner Rd., Niagara Falls, Ontario L2E 6S5, Canada.
Bioorg Med Chem Lett. 2015 Oct 1;25(19):4114-7. doi: 10.1016/j.bmcl.2015.08.027. Epub 2015 Aug 14.
Tris(3-hydroxypropyl)phosphine (THPP) is demonstrated to be a versatile, water-soluble and air-stable reducing agent, allowing for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous-organic media. The reagent shows exceptional stability at biological pH under which condition it permits the rapid reduction of a wide range of differentially functionalized small-molecule disulfides.
三（3-羟丙基）膦（THPP）被证明是一种通用的、水溶性且在空气中稳定的还原剂，能够在水性和缓冲的水-有机介质中快速、不可逆地还原裂解二硫键。该试剂在生物pH值下表现出卓越的稳定性，在此条件下它能快速还原多种不同功能化的小分子二硫键。
