Association of -463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia.

作者信息

Natter Camilla, Polterauer Stephan, Pils Sophie, Castillo-Tong Dan Cacsire, Zeilinger Robert, Heinze Georg, Hefler Lukas, Grimm Christoph

机构信息

Department of General Gynaecology and Gynaecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Center for Medical Statistics, Informatics and Intelligent Systems, Section for Clinical Biometrics, Medical University of Vienna, Vienna, Austria.

出版信息

Arch Gynecol Obstet. 2016 Apr;293(4):865-9. doi: 10.1007/s00404-015-3869-9. Epub 2015 Aug 29.

DOI:10.1007/s00404-015-3869-9

PMID:26319155

Abstract

PURPOSE

The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer. This study evaluates the association between -463G/A MPO gene polymorphism and the risk for CIN.

METHODS

The MPO gene polymorphism (-463G/A) was investigated in 616 women with cervical intraepithelial neoplasia and in 206 healthy women. Association between MPO gene polymorphism and risk of cervical intraepithelial neoplasia were analyzed by univariate and multivariable models.

RESULTS

No significant difference in genotype distribution of the MPO gene polymorphism was observed in women with CIN and controls (p = 0.4; OR 1.2, 95 % CI 0.8-1.6). A subgroup analysis only including women with CIN did not show an association between -463G/A MPO gene polymorphism and risk for high-grade CIN (CIN 2/3) (p = 0.09; OR 1.5, 95 % CI 0.9-2.3).