白细胞介素-1 和 -6 基因的遗传变异与宫颈上皮内瘤变的风险。
Genetic variations of interleukin-1 and -6 genes and risk of cervical intraepithelial neoplasia.
机构信息
Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.
出版信息
Gynecol Oncol. 2011 Jun 1;121(3):537-41. doi: 10.1016/j.ygyno.2011.02.019. Epub 2011 Mar 3.
OBJECTIVE
To evaluate the association between five interleukin-1 (IL-1) and -6 gene polymorphisms and risk of high grade cervical intraepithelial neoplasia (CIN 2-3).
METHODS
This case-control study investigates five common IL-1 and IL-6 gene polymorphisms in 131 women with CIN 2-3 and 209 controls by pyrosequencing and polymerase chain reaction. Associations between gene polymorphisms and risk of CIN 2-3 are analysed by univariate and multivariable models. Their combined effect on the risk of CIN is evaluated by haplotype analysis.
RESULTS
In a multivariable regression model IL1A -889 (odds ratio 0.3 [95% confidence interval 0.1-0.8], p=0.01) and smoking (4.0 [1.7-9.1], p=0.001) are independently associated with the risk of high grade CIN. Haplotype analysis does not reveal any high-risk combinations for the susceptibility of CIN.
CONCLUSION
The single nucleotide polymorphism IL1A -889 is independently associated with risk of high grade CIN.
目的
评估白细胞介素-1（IL-1）和 -6 基因 5 种多态性与高级别宫颈上皮内瘤变（CIN 2-3）风险之间的关联。
方法
本病例对照研究通过焦磷酸测序和聚合酶链反应，对 131 例 CIN 2-3 患者和 209 例对照者的 5 种常见 IL-1 和 IL-6 基因多态性进行了研究。采用单变量和多变量模型分析基因多态性与 CIN 2-3 风险之间的关系。通过单体型分析评估它们对 CIN 风险的综合影响。
结果
在多变量回归模型中，IL1A-889（比值比 0.3[95%置信区间 0.1-0.8]，p=0.01）和吸烟（4.0[1.7-9.1]，p=0.001）与高级别 CIN 的风险独立相关。单体型分析并未揭示任何与 CIN 易感性相关的高危组合。
结论
单核苷酸多态性 IL1A-889 与高级别 CIN 的风险独立相关。
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