Fakhry Carole, Andersen Klaus K, Eisele David W, Gillison Maura L
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, United States.
Danish Cancer Society Research Center, Statistics, Bioinformatics and Registry Unit, Denmark.
Oral Oncol. 2015 Nov;51(11):982-984. doi: 10.1016/j.oraloncology.2015.08.006. Epub 2015 Aug 28.
Incidence rates for human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) have significantly increased in numerous developed countries in recent decades. Fortunately, HPV-positive OPC has improved survival relative to HPV-negative OPC. Given these incidence trends and survival differences, we hypothesized that OPC survivorship has increased in affected populations over time.
Poisson and Cox regression models were used to examine incidence and OPC survivorship trends in a population-based prospective registry, the Danish Cancer Registry.
In Denmark, OPC incidence (p<0.001) and median survival (p<0.001) significantly increased from 1977 to 2012. Consequently, the number of 5-year OPC survivors in the Danish population increased from 72 in 1980 to 1311 in 2010.
The long-term sequelae of curative therapy in the growing number of OPC survivors will need to be evaluated to address their unique survivorship needs.
近几十年来，许多发达国家人乳头瘤病毒阳性口咽癌（HPV阳性OPC）的发病率显著上升。幸运的是，相对于HPV阴性OPC，HPV阳性OPC患者的生存率有所提高。鉴于这些发病率趋势和生存差异，我们推测随着时间的推移，受影响人群中OPC幸存者的数量有所增加。
采用泊松回归模型和Cox回归模型，在基于人群的前瞻性登记处丹麦癌症登记处中研究OPC的发病率和生存趋势。
在丹麦，1977年至2012年期间，OPC发病率（p<0.001）和中位生存期（p<0.001）显著增加。因此，丹麦人群中5年OPC幸存者的数量从1980年的72人增加到2010年的1311人。
需要评估越来越多OPC幸存者的治愈性治疗的长期后遗症，以满足他们独特的生存需求。
