非侵入性脑刺激诱导的可塑性与运动学习能力之间的关系。
Relationship Between Non-invasive Brain Stimulation-induced Plasticity and Capacity for Motor Learning.
机构信息
Faculty of Sciences of Sport and Physical Education, Department of Physical Education, University of A Coruña, A Coruña, Spain.
Department of Neurology, John Radcliffe Hospital, Headington, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
出版信息
Brain Stimul. 2015 Nov-Dec;8(6):1209-19. doi: 10.1016/j.brs.2015.07.042. Epub 2015 Aug 6.
BACKGROUND
Cortical plasticity plays a key role in motor learning (ML). Non-invasive brain stimulation (NIBS) paradigms have been used to modulate plasticity in the human motor cortex in order to facilitate ML. However, little is known about the relationship between NIBS-induced plasticity over M1 and ML capacity.
HYPOTHESIS
NIBS-induced MEP changes are related to ML capacity.
METHODS
56 subjects participated in three NIBS (paired associative stimulation, anodal transcranial direct current stimulation and intermittent theta-burst stimulation), and in three lab-based ML task (serial reaction time, visuomotor adaptation and sequential visual isometric pinch task) sessions.
ANALYSIS
After clustering the patterns of response to the different NIBS protocols, we compared the ML variables between the different patterns found. We used regression analysis to explore further the relationship between ML capacity and summary measures of the MEPs change. We ran correlations with the "responders" group only.
RESULTS
We found no differences in ML variables between clusters. Greater response to NIBS protocols may be predictive of poor performance within certain blocks of the VAT. "Responders" to AtDCS and to iTBS showed significantly faster reaction times than "non-responders." However, the physiological significance of these results is uncertain.
CONCLUSION
MEP changes induced in M1 by PAS, AtDCS and iTBS appear to have little, if any, association with the ML capacity tested with the SRTT, the VAT and the SVIPT. However, cortical excitability changes induced in M1 by AtDCS and iTBS may be related to reaction time and retention of newly acquired skills in certain motor learning tasks.
背景
皮质可塑性在运动学习（ML）中起着关键作用。非侵入性脑刺激（NIBS）范式已被用于调节人类运动皮层的可塑性，以促进 ML。然而，人们对 NIBS 诱导的 M1 可塑性变化与 ML 能力之间的关系知之甚少。
假设
NIBS 诱导的 MEP 变化与 ML 能力有关。
方法
56 名受试者参加了三种 NIBS（配对联想刺激、阳极经颅直流电刺激和间歇性 theta 爆发刺激）和三种基于实验室的 ML 任务（序列反应时间、视觉运动适应和顺序视觉等距捏合任务）。
分析
在对不同 NIBS 方案的反应模式进行聚类后，我们比较了在不同模式下发现的 ML 变量。我们使用回归分析进一步探讨了 ML 能力与 MEP 变化综合测量值之间的关系。我们仅与“应答者”组进行相关性分析。
结果
我们在聚类之间没有发现 ML 变量的差异。对 NIBS 方案的更大反应可能是在 VAT 的某些块内表现不佳的预测因素。与 iTBS 相比，AtDCS 和 iTBS 的“应答者”的反应时间明显更快。然而，这些结果的生理意义尚不确定。
结论
由 PAS、AtDCS 和 iTBS 引起的 M1 中的 MEP 变化似乎与 SRTT、VAT 和 SVIPT 测试的 ML 能力没有任何关联。然而，AtDCS 和 iTBS 引起的 M1 皮质兴奋性变化可能与某些运动学习任务中的反应时间和新获得技能的保留有关。
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