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巴西东南部人群行Roux-en-Y胃旁路术后12个月的体重减轻及代谢结果

WEIGHT LOSS AND METABOLIC OUTCOMES 12 MONTHS AFTER ROUX-EN-Y GASTRIC BYPASS IN A POPULATION OF SOUTHEASTERN BRAZIL.

作者信息

Pinhel Marcela A S, Nicoletti Carolina F, de Oliveira Bruno A P, Chaves Raoana Cássia Paixão, Parreiras Luciana Tabajara, Sivieri Thiago, Vulcano Vinicius M C, Luz Gabriela R L, Annunciato Danielle R, Morgado Luiza M A, Marcatto Gustavo, Salgado Junior Wilson, Souza Dorotéia R S, Nonino Carla Barbosa

机构信息

Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto - SP (Brazil)..

Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto - SP (Brazil)..

出版信息

Nutr Hosp. 2015 Sep 1;32(3):1017-21. doi: 10.3305/nh.2015.32.3.9274.

Abstract

UNLABELLED

BACKGROUNGD: previous outcome research in bariatric surgery has to document positive changes in co-morbidities associated with obesity.

OBJECTIVE

the study aimed report a description of the impact of bariatric surgery on weight loss and on the resolution of diseases associated with obesity in patients followed up for 12 months in the public health service of São Paulo/Brazil.

METHODS

the study was conducted on the data for 598 selected patients with grade III obesity subjected to Rouxen- Y gastric bypass evaluated postoperatively and 6 and 12 months after surgery. Anthropometric, demographic and biochemical data and personal history were determined at each time point. Serum glucose, total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were determined in the biochemical evaluation. Data were analyzed statistically by the Chi-square test, by ANOVA followed by the Bonferroni post-test and by the Student t-test for independent data, significance set at p < 0.05.

RESULTS

weight loss of 45.5 ± 13.7kg (33.5%) was observed during the first year after surgery. Serum glucose, total cholesterol and LDL cholesterol were reduced during the first six months after surgery and the values were maintained up to 12 months, whereas weight and triglycerides were reduced throughout the study period. A reduced prevalence of diabetes mellitus and dyslipidemia was observed after surgery (p < 0.001).

CONCLUSIONS

Roux-en-Y gastric bypass is an important procedure for weight loss and control of comorbidities such as diabetes and dyslipidemia at least during the first postoperative year.

摘要

未标注

背景:以往关于减肥手术的结果研究必须记录与肥胖相关的合并症的积极变化。

目的

本研究旨在报告在巴西圣保罗公共卫生服务机构对患者进行12个月随访期间,减肥手术对体重减轻以及与肥胖相关疾病缓解的影响描述。

方法

本研究基于598例接受Roux-en-Y胃旁路手术的III级肥胖患者的数据进行,术后以及术后6个月和12个月进行评估。在每个时间点测定人体测量学、人口统计学和生化数据以及个人病史。生化评估中测定血清葡萄糖、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯。数据采用卡方检验、方差分析后进行Bonferroni事后检验以及独立数据的Student t检验进行统计学分析,显著性设定为p < 0.05。

结果

术后第一年观察到体重减轻45.5±13.7kg(33.5%)。术后前六个月血清葡萄糖、总胆固醇和低密度脂蛋白胆固醇降低,这些值维持到12个月,而体重和甘油三酯在整个研究期间都降低。术后观察到糖尿病和血脂异常的患病率降低(p < 0.001)。

结论

至少在术后第一年,Roux-en-Y胃旁路手术是减肥以及控制糖尿病和血脂异常等合并症的重要手术。

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