Sanhueza Catalán Julio, Durán Agüero Samuel, Torres García Jairo
Laboratorio de Lípidos y Antioxidantes, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile..
Carrera de Nutrición y Dietética, Facultad de Ciencias de la Salud. Universidad San Sebastián..
Nutr Hosp. 2015 Sep 1;32(3):1362-75. doi: 10.3305/nh.2015.32.3.9276.
The functionality of the eukaryotic cell depends on the cell membrane, the genetic information and action of different organelles with or without the presence of membranes. The functionality of the cell membrane and organelles containing it depends primarily on the type and location of fatty acids in the phospholipids and the type of enzymes associated with them, this allows the fatty acids to be metabolized to new species that exert various functions. From this perspective, some essential fatty acids (EFAs) that produce metabolites that exert health benefits are identified, (for example antiinflammatory, neuroprotection, etc) and exert negative effects metabolites (eg inflammation, necrosis promoters, atheroma, etc.) are also generated. In general, these adverse or beneficial effects depend on the ratio of omega-6/omega-3 obtained in the diet. Thus, the higher this ratio is more negative effect; therefore the challenge of the current supply is obtained through food consumption, lower ratios in these fatty acids. The present review aims to present recent evidence on the effects of some AGEs, and the role of diet in maintaining health.
真核细胞的功能取决于细胞膜、遗传信息以及不同细胞器(无论有无膜结构)的作用。细胞膜及其所含细胞器的功能主要取决于磷脂中脂肪酸的类型和位置以及与之相关的酶的类型,这使得脂肪酸能够代谢为发挥各种功能的新物质。从这个角度来看,一些能产生具有健康益处代谢产物的必需脂肪酸(如抗炎、神经保护等)被确定,同时也会产生具有负面影响的代谢产物(如炎症、坏死促进剂、动脉粥样硬化等)。一般来说,这些不良或有益影响取决于饮食中ω-6/ω-3的比例。因此,这个比例越高,负面影响越大;所以当前通过食物消费获取的这些脂肪酸比例较低是一大挑战。本综述旨在介绍一些晚期糖基化终产物(AGEs)作用的最新证据以及饮食在维持健康中的作用。