醛脱氢酶与癌症干细胞。
Aldehyde dehydrogenases and cancer stem cells.
作者信息
Xu Xia, Chai Shoujie, Wang Pingli, Zhang Chenchen, Yang Yiming, Yang Ying, Wang Kai
机构信息
Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
出版信息
Cancer Lett. 2015 Dec 1;369(1):50-7. doi: 10.1016/j.canlet.2015.08.018. Epub 2015 Aug 28.
Aldehyde dehydrogenases (ALDHs), as essential regulators of aldehyde metabolism in the human body, protect organisms from damage induced by active aldehydes. Given their roles in different cancer types, ALDHs have been evaluated as potential prognostic markers of cancer. ALDHs exhibit high activity in cancer stem cells (CSCs) and may serve as markers of CSCs. Moreover, studies indicated that ALDHs and their regulated retinoic acid, reactive oxygen species and reactive aldehydes metabolism were strongly related with various properties of CSCs. Besides, recent research evidences have demonstrated the transcriptional and post-translational regulation of ALDH expression and activation in CSCs. Thus, this review focuses on the function and regulation of ALDHs in CSCs, particularly ALDH1A1 and ALDH1A3.
醛脱氢酶（ALDHs）作为人体醛代谢的关键调节因子，可保护机体免受活性醛诱导的损伤。鉴于其在不同癌症类型中的作用，ALDHs已被评估为癌症潜在的预后标志物。ALDHs在癌症干细胞（CSCs）中表现出高活性，并可能作为CSCs的标志物。此外，研究表明，ALDHs及其调节的视黄酸、活性氧和活性醛代谢与CSCs的各种特性密切相关。此外，最近的研究证据表明了CSCs中ALDH表达和激活的转录和翻译后调控。因此，本综述重点关注ALDHs在CSCs中的功能和调控，特别是ALDH1A1和ALDH1A3。
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