Suzuki Atsushi, Ueda Sahoko Sekiguchi, Kakita Ayako
Division of Endocrinology and Metabolism, Fujita Health University, Japan.
Clin Calcium. 2015 Sep;25(9):1367-72.
Glucocorticoid and sex-steroid deprivation therapies are two major causes of medication-related osteoporosis. As clinical course of osteoporosis is rather chronic, other drugs for common chronic diseases could also affect the incidence of osteoporotic fracture. Peroxisome proliferator-activated receptor-γ agonist, loop diuretics, selective serotonin reuptake inhibitor, anticonvulsants and proton pump inhibitors are now considered to be important candidates as the cause of medication-related osteoporosis.
糖皮质激素和性腺类固醇剥夺疗法是药物相关性骨质疏松症的两大主要病因。由于骨质疏松症的临床病程相当漫长,治疗其他常见慢性病的药物也可能影响骨质疏松性骨折的发生率。过氧化物酶体增殖物激活受体γ激动剂、袢利尿剂、选择性5-羟色胺再摄取抑制剂、抗惊厥药和质子泵抑制剂目前被认为是药物相关性骨质疏松症病因的重要候选因素。