Arimori K, Wakayama K, Nakano M
Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3148-9. doi: 10.1248/cpb.37.3148.
The characteristics of exsorption and/or excretion of theophylline into the small intestinal lumen in rats with hepatic cirrhosis (HC rats) induced by carbon tetrachloride were investigated by an in situ single-pass perfusion technique. The serum concentrations of theophylline after i.v. administration of aminophylline (10 mg/kg) in the HC rats were significantly higher than those in normal rats during the experimental period. Moreover, the exsorption of theophylline from blood into the intestinal lumen was significantly increased in the HC rats compared with the normal rats. Treatments with oral activated charcoal reduced the serum theophylline levels in the HC rats. Consequently, gastrointestinal dialysis by oral administration of activated charcoal may be a useful method to remove poisonous drugs from the blood in patients with hepatic failure (including cirrhosis), which decreases the systemic clearance.
采用原位单通道灌注技术，研究了四氯化碳诱导的肝硬化大鼠（HC大鼠）中茶碱向小肠肠腔的外排和/或排泄特征。在实验期间，静脉注射氨茶碱（10mg/kg）后，HC大鼠的血清茶碱浓度显著高于正常大鼠。此外，与正常大鼠相比，HC大鼠中茶碱从血液向外排至肠腔的量显著增加。口服活性炭治疗可降低HC大鼠的血清茶碱水平。因此，口服活性炭进行胃肠透析可能是一种从肝功能衰竭（包括肝硬化）患者血液中清除有毒药物的有效方法，肝功能衰竭会降低全身清除率。
