瘤胃对大鼠中茄属植物软刺茄维生素D样活性的修饰作用。

Modification by rumen of vitamin D-like activity of Solanum malacoxylon in rats.

作者信息

de Boland A R, Esparza M, Gallego S, Skliar M I, Boland R L

出版信息

Acta Physiol Lat Am. 1979;29(6):285-90.

Abstract

The biological activity of aqueous extracts of Solanum malacoxylon (SM) and of extracts preincubated with ruminal fluid (SMRF) on calcium and phosphate metabolism in vitamin D depleted rats was compared. The responses in intestinal 32P and 45Ca absorption, measured in an isolated duodenal loop in situ after a single oral dose, were qualitatively similar to that of 1,25-OH2-vit.D3. However, the effects elicited by SMRF were significantly higher than those caused by SM. Both extracts were equally effective in promoting bone resorption when administered orally or subcutaneously. These results provide a basis to explain the greater effectiveness of SMRF to produce calcinosis in rats. The hypothesis is advanced that biologically active steroidal metabolites with predominant action on intestine, are formed during incubation with rumen.

摘要

比较了马铃薯（Solanum malacoxylon，SM）水提取物以及与瘤胃液预孵育的提取物（SMRF）对维生素D缺乏大鼠钙和磷代谢的生物活性。单次口服给药后，在原位分离十二指肠肠袢中测量的肠道32P和45Ca吸收反应在性质上与1,25-OH2-维生素D3相似。然而，SMRF引起的效应明显高于SM引起的效应。口服或皮下给药时，两种提取物在促进骨吸收方面同样有效。这些结果为解释SMRF在大鼠中产生钙质沉着症的更大有效性提供了依据。提出的假设是，在与瘤胃孵育过程中形成了对肠道具有主要作用的生物活性甾体代谢产物。