小儿肉瘤的伊立替康治疗十五年：下一步何去何从？
Fifteen years of irinotecan therapy for pediatric sarcoma: where to next?
作者信息
Wagner Lars M
机构信息
Division of Pediatric Hematology/Oncology, Kentucky Clinic Suite, University of Kentucky, J-457, Lexington, KY 40536 USA.
出版信息
Clin Sarcoma Res. 2015 Aug 28;5:20. doi: 10.1186/s13569-015-0035-x. eCollection 2015.
Abstract
Over the past 15 years, irinotecan has emerged as an important agent for treating pediatric sarcoma patients. This review summarizes the activity noted in previous studies, and outlines current issues regarding scheduling, route of administration, and amelioration of side effects. Also discussed are new pegylated and nanoliposomal formulations of irinotecan and its active metabolite, SN-38, as well as future plans for how irinotecan may be used in combination with other conventional cytotoxic as well as targeted agents.
摘要
在过去15年里，伊立替康已成为治疗小儿肉瘤患者的一种重要药物。本综述总结了既往研究中观察到的活性，并概述了关于给药方案、给药途径和副作用改善方面的当前问题。还讨论了伊立替康及其活性代谢产物SN-38的新型聚乙二醇化和纳米脂质体制剂，以及伊立替康与其他传统细胞毒性药物和靶向药物联合使用的未来计划。
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