局部用氟米龙与双氯芬酸钠治疗常年性变应性结膜炎的对比研究
Topical Fluorometholone Versus Diclofenac Sodium in Cases With Perennial Allergic Conjunctivitis.
作者信息
Li Zhiwei, Chen Wei, Zhang Yong, Jhanji Vishal, Fan Zhaoshan, Mu Guoying
机构信息
Department of Ophthalmology (Z.L., Y.Z., Z.F., G.M.), Provincial Hospital, Shandong University, Ji'nan, China; Tian'Jin Eye Hospital (W.C.), Tianjin, China; and Department of Visual Sciences and Ophthalmology (V.J.), The Chinese University of Hong Kong, Hong Kong, China.
出版信息
Eye Contact Lens. 2015 Sep;41(5):310-3. doi: 10.1097/ICL.0000000000000127.
PURPOSE
To compare the efficacy of diclofenac sodium (DS) 0.1% and fluorometholone (FL) 0.1% in patients with perennial allergic conjunctivitis.
METHODS
Fluorometholone 0.1% or DS 0.1% eye drops were topically administrated 4 times daily for 4 weeks in patients with perennial allergic conjunctivitis. Assessment was conducted with a 4-point rating scale (0=none, 1=mild, 2=moderate, and 3=severe) for 4 signs and 5 symptoms.
RESULTS
Two hundred sixty-one patients were recruited. The demographics and baseline skin prick scores between both groups were comparable. Mean baseline scores in DS and FL group were 6.77 ± 2.24 and 6.34 ± 2.10, respectively. The scores rapidly decreased to 3.28 ± 1.47 and 2.69 ± 1.44 on day 7. Diclofenac sodium expressed a slower effect compared with FL within the first 3 days of treatment (P=0.01).
CONCLUSIONS
The efficacy of topical FL and DS was comparable for the management of cases with perennial allergic conjunctivitis. However, FL led to a more rapid alleviation of signs and symptoms as compared with DS in early days after the initiation of treatment.
目的
比较0.1%双氯芬酸钠（DS）和0.1%氟米龙（FL）治疗常年性变应性结膜炎的疗效。
方法
对常年性变应性结膜炎患者局部应用0.1%氟米龙或0.1%双氯芬酸钠滴眼液，每日4次，共4周。采用4分制评分量表（0=无，1=轻度，2=中度，3=重度）对4种体征和5种症状进行评估。
结果
共招募261例患者。两组患者的人口统计学特征和基线皮肤点刺试验评分具有可比性。DS组和FL组的平均基线评分别为6.77±2.24和6.34±2.10。在第7天时，评分迅速降至3.28±1.47和2.69±1.44。在治疗的前3天内，双氯芬酸钠的效果比氟米龙慢（P=0.01）。
结论
局部应用氟米龙和双氯芬酸钠治疗常年性变应性结膜炎的疗效相当。然而，在开始治疗后的早期，与双氯芬酸钠相比，氟米龙能更快地缓解体征和症状。
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